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Index > Protein center > Vcl(Gene name) > Mouse
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  • Vcl (Gene name),
  • Vinculin (Protein name ),  VINC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Vcl;
    Protein name:
    Vinculin;
    Alternative:
    Metavinculin;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Exhibits self-association properties. Interacts with NRAP, SORBS1 and TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
    Function:
    Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell junction adherens junction Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
    Protein Attributes:
    Sequence length:
    1066
    Sequence:
    50:
    MPVFHTRTIE | SILEPVAQQI | SHLVIMHEEG | EVDGKAIPDL | TAPVAAVQAA | 
    100:
    VSNLVRVGKE | TVQTTEDQIL | KRDMPPAFIK | VENACTKLVQ | AAQMLQSDPY | 
    150:
    SVPARDYLID | GSRGILSGTS | DLLLTFDEAE | VRKIIRVCKG | ILEYLTVAEV | 
    200:
    VETMEDLVTY | TKNLGPGMTK | MAKMIDERQQ | ELTHQEHRVM | LVNSMNTVKE | 
    250:
    LLPVLISAMK | IFVTTKNSKN | QGIEEALKNR | NFTVEKMSAE | INEIIRVLQL | 
    300:
    TSWDEDAWAS | KDTEAMKRAL | ASIDSKLNQA | KGWLRDPNAS | PGDAGEQAIR | 
    350:
    QILDEAGKVG | ELCAGKERRE | ILGTCKMLGQ | MTDQVADLRA | RGQGASPVAM | 
    400:
    QKAQQVSQGL | DVLTAKVENA | ARKLEAMTNS | KQSIAKKIDA | AQNWLADPNG | 
    450:
    GPEGEEQIRG | ALAEARKIAE | LCDDPKERDD | ILRSLGEIAA | LTSKLGDLRR | 
    500:
    QGKGDSPEAR | ALAKQVATAL | QNLQTKTNRA | VANSRPAKAA | VHLEGKIEQA | 
    550:
    QRWIDNPTVD | DRGVGQAAIR | GLVAEGHRLA | NVMMGPYRQD | LLAKCDRVDQ | 
    600:
    LTAQLADLAA | RGEGESPQAR | ALASQLQDSL | KDLKAQMQEA | MTQEVSDVFS | 
    650:
    DTTTPIKLLA | VAATAPPDAP | NREEVFDERA | ANFENHSGRL | GATAEKAAAV | 
    700:
    GTANKSTVEG | IQASVKTARE | LTPQVISAAR | ILLRNPGNQA | AYEHFETMKN | 
    750:
    QWIDNVEKMT | GLVDEAIDTK | SLLDASEEAI | KKDLDKCKVA | MANIQPQMLV | 
    800:
    AGATSIARRA | NRILLVAKRE | VENSEDPKFR | EAVKAASDEL | SKTISPMVMD | 
    850:
    AKAVAGNISD | PGLQKSFLDS | GYRILGAVAK | VREAFQPQEP | DFPPPPPDLE | 
    900:
    QLRLTDELAP | PKPPLPEGEV | PPPRPPPPEE | KDEEFPEQKA | GEVINQPMMM | 
    950:
    AARQLHDEAR | KWSSKGNDII | AAAKRMALLM | AEMSRLVRGG | SGTKRALIQC | 
    1000:
    AKDIAKASDE | VTRLAKEVAK | QCTDKRIRTN | LLQVCERIPT | ISTQLKILST | 
    1050:
    VKATMLGRTN | ISDEESEQAT | EMLVHNAQNL | MQSVKETVRE | AEAASIKIRT | 
    1066:
    DAGFTLRWVR | KTPWYQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Vinculin
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    ELISA Kit for Mouse Vinculin
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    ELISA Kit for Mouse Vinculin
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    ELISA Kit for Mouse Vinculin
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    ELISA Kit for Mouse Vinculin
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    CLIA Kit for Mouse Vinculin
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    CLIA Kit for Mouse Vinculin
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    CLIA Kit for Mouse Vinculin
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    CLIA Kit for Mouse Vinculin
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    U1839r
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    CLIA Kit for Mouse Vinculin
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    Polyclonal Antibody for Mouse Vinculin
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    P1839Rb-h
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    Polyclonal Antibody for Mouse Vinculin
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Vinculin
    Polyclonal Antibody for Mouse Vinculin
    Polyclonal Antibody for Mouse Vinculin
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    P1839Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Vinculin
    Monoclonal Antibody for Mouse Vinculin
    Monoclonal Antibody for Mouse Vinculin
    Monoclonal Antibody for Mouse Vinculin
    Monoclonal Antibody for Mouse Vinculin
    Protein for Mouse Vinculin
    Protein for Mouse Vinculin
    Protein for Mouse Vinculin
    Protein for Mouse Vinculin
    Protein for Mouse Vinculin

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    References
    1. 1.
      "Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion."
      Coll J.-L. , Ben-Ze'ev A. , Ezzell R.M. , Rodriguez Fernandez J.L. , Baribault H. , Oshima R.G. , Adamson E.D.
      Proc. Natl. Acad. Sci. U.S.A.92:9161-9165(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION
      strain: 129/SvJ.
      tissue: Embryo.
    2. 2.
      "Vinculin gene is non-essential in Drosophila melanogaster."
      Alatortsev V.E. , Kramerova I.A. , Frolov M.V. , Lavrov S.A. , Westphal E.D.
      FEBS Lett.413:197-201(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Forelimb.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 286-300; 656-666 AND 916-924;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    6. 6.
      "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions."
      Mandai K. , Nakanishi H. , Satoh A. , Takahashi K. , Satoh K. , Nishioka H. , Mizoguchi A. , Takai Y.
      J. Cell Biol.144:1001-1017(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORBS1
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    9. 9.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290 AND SER-721;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    10. 10.
      "Vinculin's C-terminal region facilitates phospholipid membrane insertion."
      Wirth V.F. , List F. , Diez G. , Goldmann W.H.
      Biochem. Biophys. Res. Commun.398:433-437(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGION INVOLVED IN PHOSPHOLIPID MEMBRANE INSERTION
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